1994 - Bachelor of Sciences, Faculty of Sciences of Charles’ University in Prague
1996 - Master of Sciences summa cum laude, Faculty of Sciences of Charles’ University in Prague
2000 - Ph.D. in molecular and cellular biology, Faculty of Biology of South Bohemian University in České Budějovice, the Czech Republic
GRANTS AND FELLOWSHIPS
2000 Complementary postdoctoral grant GAAV CR, The changes in the activity of cyclin dependent kinase and in phosphorylation of their target proteins during the algal cell cycle under presence of heavy metals
2001-2003 Postdoctoral fellowship of Japan Society for the Promotion of the Science
2006-2008 grant GACR, Regulation of mitosis by plant specific cyclin-dependent kinase B in green alga Chlamydomonas reinhardtii
2006-2010 grant GAAV CR Regulation of mitosis by WEE1 kinase in green alga Chlamydomonas reinhardtii
2009-2011 grant GACR, Generation of temperature sensitive cell division cycle mutants in green alga Chlamydomonas reinhardtii
2009 grant AS CR The role of CDKB1 and WEE1 kinases in the moss Physcomitrella patens
RESEARCH EXPERIENCE
2006 – up to now, principal investigator, Laboratory of Cell Cycle of Algae, Department of Autotrophic Microorganisms, Institute of Microbiology, Academy of Sciences of the Czech Republic, Třeboň, the Czech Republic
2004 – 2006, postdoctoral stay, Plant Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA, supervisor Dr. James G. Umen
2001 – 2003, postdoctoral stay, Laboratory of Cellular Functions, Institute of Molecular and Cellular Biosciences, the University of Tokyo, Tokyo, Japan, supervisor Dr. Masaaki Umeda
1996 – 2001, graduate school, Cell Cycle Laboratory, Department of Autotrophic Microorganisms, Institute of Microbiology, Academy of Sciences of the Czech Republic, Třeboň, the Czech Republic, supervisor Dr. Vilém Zachleder
PUBLICATION ACTIVITY
Bišová, K., Vítová, M., Zachleder, V. (2000) The activity of total histone H1 kinases is related to growth and commitment points while the p13suc1-bound activity relates to mitoses in the alga Scenedesmus quadricauda, Plant Physiol. Biochem. 38, 755-764
Zachleder, V., Hendrychová, J., Bišová, K., Kubín, Š. (2002a) Factors affecting the mating competence in the unicellular green alga Chlamydomonas eugametos (Volvocales), Folia Microbiol. 47, 69-72
Zachleder, V., Bišová, K., Vítová, M., Kubín, Š., Hendrychová, J. (2002b) Variety of cell cycle patterns in the alga Scenedesmus quadricauda (Chlorophyta) as revealed by application of illumination regimes and inhibitors, Eur. J. Phycol. 37, 361-371
Hendrychová, J., Vítová, M., Bišová, K., Wiche, G., Zachleder, V. (2002) Plectin-like proteins are present in the cells of Chlamydomonas (Chlorophyta), Folia Microbiol. 47, 535-539
Slaninová, N., Nagyová, B., Gálová, E., Hendrychová, J., Bišová, K., Zachleder, V., Vlček, D. (2003) The alga Chlamydomonas reinhardtii UVS11 gene is responsible for cell division delay and temporal decrease of histone H1 kinase activity caused by UV irradiation, Genetics, DNA repair 2, 737-750
Bišová, K., Hendrychová, J., Cepák, V., Zachleder, V. (2003) Cell growth and division processes are differentially sensitive to cadmium in Scenedesmus, Folia Microbiol. 48, 805-816
Shimotohno, A., Umeda-Hara, C., Bišová, K., Uchimiya, H., Umeda, M. (2004) The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis, Plant Cell 16(11), 2954-66
Bisova, K., Krylov, D. M., Umen, J. G., (2005) Genome-wide annotation and expression profilig of cell cycle regulatory genes in Chlamydomonas reinhardtii, Plant Physiol. 137, 1-17
Shimotohno, A., Ohno, R.., Bišová, K., Sakaguchi, N., Huang, J., Koncz, C., Uchimiya, H., Umeda, M., (2006) Diverse phosphoregulatory mechanisms controlling cyclin-dependent kinase-activating kinases in Arabidopsis, Plant J. 47, 701-10
Merchant, S. S., Prochnik, S. E., Vallon, O., Harris, E. H., Karpowicz, S. J., Witman, G. B., Terry, A., Salamov, A., Fritz-Laylin, L. K., Maréchal-Drouard, L., Marshall, W. F., Qu, L. H., Nelson, D. R., Sanderfoot, A. A., Spalding, M. H., Kapitonov, V. V., Ren, Q., Ferris, P., Lindquist, E., Shapiro, H., Lucas, S. M., Grimwood, J., Schmutz, J., Cardol, P., Cerutti, H., Chanfreau, G., Chen, C. L., Cognat, V., Croft, M. T., Dent, R., Dutcher, S., Fernández, E., Fukuzawa, H., González-Ballester, D., González-Halphen, D., Hallmann, A., Hanikenne, M., Hippler, M., Inwood, W., Jabbari, K., Kalanon, M., Kuras, R., Lefebvre, P. A., Lemaire, S. D., Lobanov, A. V., Lohr, M., Manuell, A., Meier, I., Mets, L., Mittag, M., Mittelmeier, T., Moroney, J. V., Moseley, J., Napoli, C., Nedelcu, A. M., Niyogi, K., Novoselov, S. V., Paulsen, I. T., Pazour, G., Purton, S., Ral, J. P., Ria?o-Pachón, D. M., Riekhof, W., Rymarquis, L., Schroda, M., Stern, D., Umen, J., Willows, R., Wilson, N., Zimmer, S. L., Allmer, J., Balk, J., Bisova K., Chen, C. J., Elias, M., Gendler, K., Hauser, C., Lamb, M. R., Ledford, H., Long, J. C., Minagawa, J., Page, M. D., Pan, J., Pootakham, W., Roje, S., Rose, A., Stahlberg, E., Terauchi, A. M., Yang, P., Ball, S., Bowler, C., Dieckmann, C. L., Gladyshev, V. N., Green, P., Jorgensen, R., Mayfield, S., Mueller-Roeber, B., Rajamani, S., Sayre, R. T., Brokstein, P., Dubchak, I., Goodstein, D., Hornick, L., Huang, Y. W., Jhaveri, J., Luo, Y., Martínez, D., Ngau, W. C., Otillar, B., Poliakov, A., Porter, A., Szajkowski, L., Werner, G., Zhou, K., Grigoriev, I. V., Rokhsar, D. S., Grossman, A. R., (2007) The Chlamydomonas genome reveals the evolution of key animal and plant functions, Science 318, 245-250
Čížková, M., Pichová, A., Vítová, M., Hlavová, M., Hendrychová, J., Umysová, D., Gálová, E., Ševčovičová, A., Zachleder, V., Umen, J. G., Bišová, K., (2008) CDKA and CDKB kinases from Chlamydomonas reinhardtii are able to complement cdc28 temperature-sensitive mutants of Saccharomyces cerevisiae, Protoplasma 232, 183-191
Bišová, K., (2008) Cell growth control in an algal model, In L Bogre, GTS Beemster, Eds, Plant growth signalling. Springer-Verlag, Berlin Heidelberg, Pp 351-373
Vítová, M., Hendrychová, J., Čížková, M., Cepák, V., Umen, J. G., Zachleder, V., Bišová, K. (2008) Accumulation, activity and localization of cell cycle regulatory proteins and the chloroplast dvision protein FtsZ in the alga Scenedesmus quadricauda under inhibition of nuclear DNA replication, Plant Cell Physiol. 49, 1805-1817
Umysová, D., Vítová, M., Doušková, I., Bišová, K., Hlavová, M., Čížková, M., Machát, J., Doucha, J., Zachleder, V. (2009) Bioaccumulation and toxicity of selenium compounds in the green alga Scenedesmus quadricauda, BMC Plant Biol. 9, 58
Olson BJ., Oberholzer M., Li Y., Zones JM., Kohli HS., Bisova K., Fang SC., Meisenhelder J., Hunter T., Umen JG. (2010) Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex, Plant Cell 22, 3331-3347
Vítová M., Bišová K., Umysová D., Hlavová M., Kawano S., Zachleder V., Čížková M. (2011) Chlamydomonas reinhardtii: duration of its cell cycle and phases at growth rates affected by light intensity, Planta 233, 75-86
Vítová, M., Bišová, K., Hlavová, M., Zachleder, V., Čížková, M. (2011) Glutathione peroxidase activity in the selenium-treated alga Scenedesmus quadricauda, Aquatic Toxicol. 102, 87-94
Brányiková I., Maršálková B., Doucha J., Brányik T., Bišová K., Zachleder V., Vítová M. (2011) Microalgae-novel highly efficient starch producers, Biotechnol. Bioeng. 108, 766-776
Hlavová, M., Èížková, M., Vítová, M., Bišová, K., Zachleder, V. (2011) DNA damage during G2 phase does not affect cell cycle progression of the green alga Scenedesmus quadricauda, PLoS ONE 6, e19626
Vítová, M., Bišová, K., Umysová, D., Hlavová, M., Kawano, S., Zachleder, V., Čížková, M. (2011) Chlamydomonas reinhardtii: Duration of its cell cycle and phases at growth rates affected by temperature, Planta DOI 10.1007/s00425-011-1427-7
born 6. 5. 1973 in Prague, the Czech Republic